Two alchemist brothers go on a quest for the Philosopher's Stone after an attempt to revive their dead mother goes horribly wrong.
Munich, Germany, 1923. Two years have passed since Edward Elric was dragged from his own world to ours, leaving behind his country, his friends and his younger brother, Alphonse. Stripped of his alchemical powers, he has been all this time researching rocketry together with Alphonse Heiderich, a young man who resembles his own brother, hoping to one day find a way back home. His efforts so far had proven fruitless, but after lending a hand to a troubled gipsy girl, Edward is thrown in a series of events that can wreak havoc in both worlds. Meanwhile, at his own world, Alphonse Elric ventures deeper into the mysteries of alchemy in search for a way to reunite with his older brother.
After a mysterious prisoner with only a few weeks left on his sentence breaks out of prison in Central City, the Elric brothers attempt to track him down. The search leads them to Table City in the southwestern country of Creta, where Alphonse rescues a young alchemist named Julia from the very man they are trying to capture. In the thick of the fight, they literally tumble into Julia's home turf, the slums of Milos Valley, and are embroiled in the grassroots rebellion of her people.
Edward and Alphonse Elric are two brothers gifted with the ability of alchemy, the science of taking one thing and changing it into another. However, alchemy works on the theory of Equivalent Exchange -- for something to be created, something else of equal value must be sacrificed. When their mother dies, Edward decides to do the unthinkable -- bringing her back to life by breaking one of Alchemy's biggest taboos and performing Human Alchemy. Thinking they have nothing more to lose, he and Alphonse make their attempt -- but something goes horribly wrong. In the process, Alphonse loses his body and Edward loses his leg. Ed manages to save Al by attaching his spirit to a suit of armor, but at the cost of his arm and leg.
Edward and Alphonse Elric's reckless disregard for alchemy's fundamental laws ripped half of Ed's limbs from his body and left Al's soul clinging to a cold suit of armor. To restore what was lost, the brothers scour a war-torn land for the Philosopher's Stone, a fabled relic which grants the ability to perform alchemy in impossible ways. The Elrics are not alone in their search; the corrupt State Military is also eager to harness the artifact's power. So too are the strange Homunculi and their shadowy creator. The mythical gem lures exotic alchemists from distant kingdoms, scarring some deeply enough to inspire murder. As the Elrics find their course altered by these enemies and allies, their purpose remains unchanged – and their bond unbreakable.